| LC-MS/MS Triple Quadrupole with ESI, APC, Pesticide Primary Metabolites, and Fatty acid Method Package |
| Features:Triple Quadrupole Liquid Chromatography Mass Spectroscopy for both qualitative and quantitative analysis.The LC-MS/MS must be able to analysis quantitative and qualitative data simultaneously.The system must be unique approach to delivering high quality and high-speed LC- MS/MS analysis must combine the Nexera UHPLC or better and latest LCMS as seamlessly integrated system.High sensitivity & high-speed scanning at 30,000u/sec or better.Should be capable to simultaneous high-speed screening of 12 toxicological drugs. High sensitivity & high-speed MRM at 555 MRM/sec or better.Should be capable of detecting target compounds at trace-level concentrations.Must be capable for simultaneous analysis above 830 pesticides for water quality analysis. High sensitivity for trace quantitative analysis.UF-MRM: Must be with UF sweeper III high-speed ion transport technology to minimizes ion loss even at a dwell time of 0.8 msec or less.Heated ESI probe: Must be with high temperature gas supplements to improve desolvation efficiency, with newly developed heated ESI probe combines a high- temperature gas with the nebulizer spray, assisting in the desolvation of large droplets and facilitating ionization.Outstanding throughput and quantitative accuracy: Must be capable of measuring positive and negative ions separately with inadequate polarity switching & ultra-fast polarity switching.Efficient qualitative analysis using synchronized survey scan.UF technologies should combine sensitivity and high speed.Must be capable of achieving stable quantitative accuracy with positive/negative ionization switching within 5 msec or better.Ionization Unit: Should design without cables or tubes; utilize a one-touch lever to perform simple attachment and detachment of the unit.Must be with ultrafast response high-voltage power supply for polarity switching.Qarray: Patented Qarray ion guide design for effectively focus ions over a wide m/z range by overlapping multiple electric fields.UF Sweeper III Collision Cell: Must be with high-sensitivity, high-speed collision cell, the proprietary UF sweeper III accelerates ions out of the collision cell without loss of momentum. Should be capable to achieving fast sweeping on successive scans, offers twice efficiency of UF sweeper II, maintains signal intensity, and suppresses crosstalk, even for high-speed or simultaneous multi-component analysis.UF-Lens: Should Combines two multi-pole RF ion guides to achieve efficient ion transport and high sensitivity.Quadrupole Rod: Must be with high-performance hyperbolic mass filter with a proven track record in LC/MS, to maintains high ion transmittance and high sensitivity with high- speed scanning rate of 30,000 u/sec.Ultrafast Response Detector: The ultrafast high-voltage power supply should allow high-speed positive/negative ion mode switching of the detector voltage. |
| Technical Specifications: |
| Brand | : Shimadzu Corporation, Japan. |
| Model | : LCMS-8060NX. |
| Mass Range: | m/z 2 – 2000 Da or better |
| Resolution: | Normal resolution mode: 0.7, High resolution mode: 0.4 or better |
| Maximum Scan Speed: | 30,000 μ/s or higher in all modes of scanning with an increment of 0.1 u |
| Polarity Switching Time: | less than or equal to 5 ms |
| Minimum Dwell Time: | 0.8ms or lower |
| Minimum Pause Time: | 1msec or lower |
| Mass Stability: | 0.05 Da over 24 hours or better |
| Mass Accuracy: | ±0.1 Da or less |
| Dynamic range: | 7 order (pulse counting) or more |
| MRM Transitions Speed: | 555 MRM per sec or more. |
| Cross talk: | Must be less than 0.0005% |
| Applicable LC flow rate: | From 1 ul/min to 2 mL/min for ESI Probe |
| Ionization Probe: | Both ESI and APCI |
| Interface Maximum Temperature: For ESI: | For ESI: 6500C or higher & For APCI: 5000C or higher |
| Mass Analyzer: | Two high resolution molybdenum hyperbolic mass filters with pre-rods |
| Collision Cell: | Tapered Multipole type ultra-high-speed collision cell |
| Detector: | Secondary electron multiplier with off-axis conversion dynode. |
| Ion optical system: | Q-array ion guide and two quadrupoles for efficient and rapid ion transfer |
| Software Specifications: | Single software is used to control LCMS/MS as well as HPLC/UHPLC systems.Auto-tuning and calibration shall be standard.Automated optimization of MRM transitions should be available.An Interface optimization software feature shall be available for automated optimization of Interface parameters such Heater temperature and gas flow rate. The software shall be capable of automatic batch creation to perform analysis and acquire dataSoftware must be designed for various acquisition modes such as MS Acquisition mode and MSMS acquisition mode. The MSMS acquisition mode must have MRM mode with 1000 events and each event must have 32 channels or better.Software shall support GLP/GMP functions. |
| Method Package: | Must include LC/MS/MS Method Package for Veterinary Drugs, Residual Pesticides, Mycotoxin, DL amino acids, Short Chain Fatty Acids, Drugs of Abuse, Forensic Toxicology |
| System Specification: |
| MRM Sensitivity for Positive ESI: | By using the ESI probe, the measured signal-to-noise ratio [RMS] shall be more than or equal to 1500,000:1 on injection of 1 Pg of Reserpine. |
| MRM Sensitivity for Negative ESI: | By using the ESI probe, the measured signal-to-noise ratio [RMS] shall be more than or equal to 1500,000:1 on injection of 1 pg of Chloramphenicol. |
| Pressure Chemical Ionization (APCI): |
| MRM Sensitivity for Positive APCI: | By using the APCI probe, the measured signal-to-noise ratio [RMS] shall be more than or equal to 450,000:1 on injection of 1 pg of Reserpine. |
| Direct Probe Ionization: | Must include the kit of direct probe ionization to remove a micro quantity of liquid from the sample.Also include method package of Rapid Toc Screening for Direct Probe Ionization |
| Nitrogen Generator: | Extremely Low Noise and Vibration free gas generator with built in air compressor capable of providing all the gases [Nitrogen and zero air] required for the Mass Spectrometer must be quoted. The generator shall provide Nitrogen gas and Dry Air supply as well. It shall have internal air compressor as standard.Max Flow Rate shall be 25L/min.Max Outlet Pressure shall be 690Kpa (100 psi)Noise Level shall be 54 dB or less |
| Solvent delivery system: | Binary type or better Maximum operating pressure : 130 MPa or moreFlow-rate setting range : 0.0001-3.0000 mL/min Flow rate accuracy: ±1% or betterFlow rate precision: Less than 0.06% RSD Gradient type: High–pressure mixing.Gradient mixing accuracy: ±0.5% or betterSolvent Selection Valve must be available.Must have Mobile Phase Monitoring device |
| Auto-sample Injection: | Injection range: 0.1-50 μl or moreMaximum operating pressure: 130 MPa or moreAccuracy: ±1% or better Injection Volume Range: 0.1 to 50 ul or betterInjection Cycle Time: ≤ 6.7 seconds (under specified conditions)Cross-contamination or carry over: 0.0015% Sample temperature control: 4OC to 45OC or betterNumber of processed samples: 162 (1.5 mL sample vials) |
| Column Oven: | Temperature Control Type: Forced air circulation.Temperature precision: ±0.05oC or betterTemperature accuracy: ±0.5oC or betterTemperature control range: 10°C below room temperature to 100°CContainable column size and Number Dimensions: Up to 250 mm L. column(Qty: 06) or 300 mm L. Column(Qty: 03) or more |
| Photodiode Array (PDA) Detector | The wavelength range shall be 190 nm – 800 nm.The photo-diode array detector shall have 1024 elements.A UHPLC cell (optical path length: 10 mm, cell volume: 8 μL, equipped with temperature control function must be available as standardThe flow cells must be temperature controlled from ambient + 5ºC to 50ºC.Wavelength accuracy shall be ±1 nm.A deuterium lamp [D2] and a Tungsten lamp [W] shall be available as Light Source for UV and visible wavelengths respectively.The Drift must be smaller than 0.4×10-3 AU/HourThe Noise Level must be smaller than 4.5×10-6 AU.Linearity shall be equal or more than 2.5 AU (ASTM method) |
| System Controller: | Number of connectable units: 8 (Using option: 12)Analytical Columns: 10Nos. |
| Solvent Filtration Unit: | Solvent Filtration Unit with Pump- 01 unitMembrane filter (0.22 µm and 0.45 µm) – 500 pcs of each itemSyringe Filter (0.22 µm and 0.45 µm) – 500 pcs of each item |
| Solid Phase Extraction Unit: | Solid Phase Extraction Unit shall comprise below items- 01 unit.C18 E: 200 mg/3 mL-Qty-500 pcsISOLUTE Myco 60 mg/3 mL (Tables), 50pcs/pk- 10 pktEVOLUTE Express WCX 10 mg –Qty: 1000 pcs12-position vacuum, Manifold Set with a vacuum pump |
| QuEChERS: | QuEChERS Extraction Packets: 6.0g MgSO4, 1.5g NaOAc (10pkt)dSPE Tube 150 MgSO4 25Mg PSA 25Mg (5Pk) |
| Accessories | a) Amber colored vial (1.5 mL)- 2000 pcsb) Clear Vial (1.5 mL)- 1000 pcsc) Qsert Vial (0.3mL) Kit, Silicone /PTF Septa- 1000 pcsd) UHPLC column fitting- 5pcse) Peek Nut- 5 pcsf) PEEK TUBE,0.13X3000 – 5 pcsg) Ghost Traph) LCMS/MS tuning/Calibration standard- 1Seti) 5-channel Degassing Unit- 1No.j) Reservoir Tray- 1No. k) Reservoir Bottle- 10Nos. l) On-site Argon gas generator (99.998%)/Cylinder with Double Stage regulator- 2 Nos.m) On-site Nitrogen Gas Generator- 1 Nos.n) An installation Table with cabinet and rack. |
| Chemicals and Reagent: | a) MS grade Methanol-10Lb) MS grade formic acid -5L (2.5L bottle each)c) MS grade acetonitrile-1L. |
| Computer | Brand Computer– 1No.Dell Brand PC, Processor- Intel Core i7-11900, RAM: 16 GB, SSD: 1TB, Original Windows latest version with original MS office, Optical Drive: DVD-R/W, Monitor: 27 Inch LED. |
| Online UPS | 10 KVA On-line UPS with built-in Stabilizer, 60min back up at full load- 01 No. |
| Printer | HP/Canon Laser Printer with auto-Duplex- 1No. |
| Country of Origin: | Japan. |
| Make and assembly | Japan. |
| Certification- Country of Origin | Yes |
| Manufacturer Authorization Letter | Yes (On Manufacturer’s letterhead pad) |
| Manufacturer Warranty and guaranty | Yes (On Manufacturer’s letterhead pad) |
| Standard Warranty and guaranty | One Year |
| Extended Service Warranty | Five years (including warranty period) |
| Training | 5-days training on maintenance, trouble shooting, operation, and application of equipment will be provided by manufacturer trained engineer after installation and commissioning and 3-days after 3-months of 1st schedule training at user site. We will train up the appointed scientists/experts/technician until ready for operation. |
| Advance Foreign Training | Advance foreign training on Operation and application will be provided by us in the manufacturer country or manufacturer permitted country for 5 (five) working days. We will be borne all costs like transportation and accommodation with daily allowance as required as need in standard rules and regulation. |
| Pre-Shipment Inspection | We will have done pre-shipment inspection in manufacturer premises or manufacturer yard before the goods for end user country. We will bear all kinds of transportation cost, hotel, and food accommodation cost with daily allowance as required as need in standard rules and regulation. |
| Packing list | Packing list from manufacturer will be provided with system |
| Catalog | Manufacturer catalogue submitted in English |
| Remarks (any) | N/A |
| Price | Included. |
